LiPlaCis® is an intelligent, target controlled liposome formulation of one of the world’s most widely used chemotherapeutic agents, cisplatin, which has documented efficacy in numerous tumor types.
The specific LiPlaCis formulation allows delivery of LiPlaCis directly to the tumor site where is it needed.
How it Works
LiPlaCis, a target controlled liposome, enables a more selective up-take of cisplatin at the tumor site. Once it has accumulated in the cancer tissue, the drug is broken down by secretory phospholipase A2 (sPLA2), an enzyme present on tumors. The lipid composition of LiPlaCis is tailored to be specifically sensitive to degradation by the sPLA2 enzyme and thereby for release of the encapsulated cisplatin.
A Phase 2 clinical trial of LiPlaCis is ongoing in Denmark for the treatment of metastatic breast cancer. In October 2018 this trial , increasing the planned study cohort from 30 to 50 patients. The aim of this study is to identify the breast and prostate patient populations relevant for submitting a Marketing Authorization application. in a group of heavily pre-treated breast cancer patients who were identified as most sensitive to LiPlaCis treatment based on a DRP® analysis: 33% response rate , 4 out of twelve patients, in the upper one third of DRP® selected patients, and 40% in the upper 20% of DRP® selected patients that have not previously been treated with cisplatin.
- A partial remission is defined as a >30% reduction in tumor size as measured in one dimension by CT scan. A 30% reduction measured in only one dimension is equivalent to an estimated 66% reduction in total tumor size, since the tumor will not only have been reduced in length (one dimension) but also in height and depth. Thus, on average the tumor is reduced to 34% of its initial size, or less (0.7 x 0.7 x 0.7 * 100% = 34%).
Equipment from Oncology Venture’s labs.
History and Funding
Oncology Venture in-licensed LiPlaCis from LiPlasome Pharma in 2016. The technology behind this product candidate was originally developed by scientists from Danish Technical University (DTU).
Development of LiPlaCis is funded in part by a 2016 EUROSTARS grant, with additional funding from Smerud Medical Research.
Jakobsen EH et al. Liposomal cisplatin response prediction in heavily pretreated breast cancer patients: A multigene biomarker in a prospective phase 2 study. J Clin Oncol 36, 2018 (suppl; abstr e13077)